Summer Intern/Biology
Description of Department:
GlaxoSmithKline (GSK) is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs but finding new ways to discover drugs.
GSK’s Adaptive Immunity Research Unit (AIRU) identifies and develops novel therapeutic targets for patients with unmet medical need, through leveraging genetic, experimental and genomic approaches from genetic collaborations (23andMe, UK Biobank, Finngen), building drug hypotheses from output of functional CRISPR editing screens, driving targets through milestone governance decisions, or much more… The Genomic Immunology group, as part of AIRU, strives to explore that rich data landscape to derive crucial insight, and integrate directly with our groundbreaking experimental science. This approach maximizes the probability of delivering successful clinical candidates, and ultimately helping people to do more, feel better and live longer.
Check out the virtual tour of the GSK Greater Boston offices!
Job Description:
Our research team in Cambridge, MA is seeking a self-motivated, energetic and creative cell biologist / burgeoning immunologist to take part in the development of novel therapeutics for the treatment of immune disorders with high unmet medical need. This individual will have the opportunity to make significant and high-impact contributions in a small dynamic group setting on multiple cross-functional drug discovery programs in the areas of adaptive immunity using genomic immunology genetic, genomic and experimental approaches. Responsibilities will include:
- to perform hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation,
- to design and conduct human and rodent cell- and tissue-based immunoassays for target identification and validation,
- to generate, analyze, interpret, present experimental results at various meetings to partners/collaborators and collaboratively plan experimental paths forward
- to generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy.
- to share responsibilities in supporting general lab functions
Basic Qualifications:
- Pursuing a degree in Genetics, Cell Biology or Immunology.
- Able to work full-time (35-40 hours/week) throughout the 12-week internship cycle (May-July/August)
- Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible.
Preferred Qualifications:
- Basic understanding of cell culture: isolation and sterile tissue culture of mammalian cell lines and immune cell subsets
- Basic understanding of cell-based assay development using primary rodent and human immune cells and immortalized cell lines
- Basic understanding of molecular biology (included but not limited to Next Generation Sequencing, Microarray, CRISPR gene editing, qPCR, NanoString, scRNA-Seq)
- Basic understanding of Multicolor Flow-cytometry analysis
- Basic understanding of protein detection (included but not limited to ELISA, Luminex, MSD, Western blotting)
Eligibility Requirements:
- Successfully pass a drug screen and background check prior to assignment target start date.
- Provide your own funding for relocation and commuting.